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Knockout/Knockdown Validation

Antibodies are essential tools for both basic and clinical research. However, there has been growing distrust of commercially available antibodies with regard to specificity and performance variability. As a result, the research community and funding agencies have demanded that antibody suppliers increase their efforts to more thoroughly validate these reagents. One approach to address this is through knockout or knockdown of the target protein by CRISPR- or RNAi-mediated technologies.

Learn more about the CRISPR/Cas9 technology
Learn more about the knockdown technology

In support of this goal, GeneTex is conducting knockout/knockdown-based validation as a fundamental component of its antibody quality assurance process. To date, we have evaluated over one thousand of our most popular products covering multiple research topics, such as apoptosis, metabolism, epithelial–mesenchymal transition, and neurodegenerative diseases. We will continue to expand these efforts in the future. Antibodies that have passed the KO/KD test will be labeled with the KO/KD validated icon.

 
View All KO/KD Validated Antibodies
 

 

Highlighted Products

Apoptosis

p53 antibody [D01]
(GTX70214)

PARP antibody [N2C1], Internal (GTX112864)

Caspase 3 antibody
(GTX110543)

FOXO3A antibody [C3], C-term (GTX100277)
Metabolism

IDH1 antibody
(GTX105179)

IDH2 antibody [GT673]
(GTX628487)

Citrate synthetase antibody [N2C3] (GTX110624)

Glutamine synthetase antibody
(GTX109121)
Epithelial–mesenchymal transition

E-Cadherin antibody
(GTX100443)

Vimentin antibody [GT812]
(GTX629744)

αSMA antibody
(GTX100034)

STAT3 antibody [C3], C-term
(GTX104616)
Neurodegenerative diseases

SOD1 antibody
(GTX100554)

Huntingtin antibody (GTX132433)

HMGB1 antibody
(GTX101277)

GSK3 beta antibody [C1C3]
(GTX111192)

Share your KO/KD data with us!

If you want to share your knockout/knockdown validation data using GeneTex antibodies with us, please feel free to send us an email or contact us for further information. With your posted results, you will qualify for the GeneTex Rewards Program.