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Epithelial-Mesenchymal Transition

Epithelial-Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) is a process whereby largely adherent and polarized epithelial cells acquire the phenotype of more mobile mesenchymal cells. EMT not only facilitates morphogenesis during embryonic development but also promotes invasion and metastasis in tumors. Pathological EMT is associated with E-cadherin repression, which has been shown to contribute to tumor progression. Several oncogenic pathways (e.g., TGF-beta, Wnt/beta-catenin, integrins, and Notch) have been reported to induce EMT via cytoskeleton rearrangement and activation of E-cadherin repressors, including Snail, Slug, SIP1, ZEB1, and TCF3

    

EMT-inducing Transcription Factors

beta Catenin antibody (GTX101435)

 

SNAI1 antibody (GTX100754)

  

Twist1/2 antibody (GTX127310)

 
 

Epithelial Markers

E-Cadherin antibody (GTX100443)

  

Cytokeratin 8 antibody  (GTX112975)

 

Cytokeratin 18 antibody  (GTX112978)

 
 

Mesenchymal Markers

alpha Smooth Muscle Actin antibody (GTX100034)

 

Fibronectin antibody  (GTX112794)

  

N-Cadherin antibody (GTX127345)

 

 

Pathways
Wnt Pathway

Wnt Pathway

Wnt proteins are secreted morphogens that are required for various developmental processes.
Pathways
Epithelial–mesenchymal transition (EMT) Pathway

Epithelial–mesenchymal transition (EMT) Pathway

EMT is a process whereby tightly-interacting and immotile epithelial cells acquire the phenotype of loosely-adherent and motile mesenchymal cells.
Literature
Poster - Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Flyer - Epithelial–Mesenchymal Transition

Flyer - Epithelial–Mesenchymal Transition

Download the latest version of GeneTex's epithelial–mesenchymal transition flyer.
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Pamphlet - Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature
Poster - EMT

Poster - EMT

Download the latest version of GeneTex's EMT poster
Literature
Poster - Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Flyer - Epithelial–Mesenchymal Transition

Flyer - Epithelial–Mesenchymal Transition

Download the latest version of GeneTex's epithelial–mesenchymal transition flyer.
Literature
Pamphlet - Hot Products

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Pamphlet - Antibodies for Cancer Research

Pamphlet - Antibodies for Cancer Research

Download the latest version of GeneTex's pamphlet of antibodies for cancer research
Literature
Poster - EMT

Poster - EMT

Download the latest version of GeneTex's EMT poster